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Merck
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N3415

Sigma-Aldrich

Nifurtimox

≥98% (HPLC)

Sinonimo/i:

(RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide, (±)-Nifurtimox, 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide, BAY 2502, Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide

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About This Item

Formula empirica (notazione di Hill):
C10H13N3O5S
Numero CAS:
23256-30-6
Peso molecolare:
287.29
Numero CE:
245-531-0
Numero MDL:
MFCD00869254
Codice UNSPSC:
12352200
ID PubChem:
329818609
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

yellow to orange

Solubilità

DMSO: ≥13 mg/mL

Ideatore

Bayer

Temperatura di conservazione

room temp

Stringa SMILE

CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O

InChI

1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
ARFHIAQFJWUCFH-IZZDOVSWSA-N

Descrizione generale

Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions. It is used to treat Chagas disease and African trypanosomiasis. Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth.

Applicazioni

Nifurtimox has been used in drug treatment in culture media.

Azioni biochim/fisiol

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.

Caratteristiche e vantaggi

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Tolerance and safety of nifurtimox in patients with chronic chagas disease
Jackson Y, et al.
Clinical Infectious Diseases, 51(10), e69-e75 (2010)
Antitrypanosomal therapy for chronic Chagas' disease.
Caryn Bern
The New England journal of medicine, 364(26), 2527-2534 (2011-07-01)
Anis Rassi et al.
Infectious disease clinics of North America, 26(2), 275-291 (2012-05-29)
Chagas disease, also known as American trypanosomiasis, is a chronic infection caused by Trypanosoma cruzi, a protozoan parasite. It is transmitted to human beings mainly through the feces of infected triatomine bugs. The disease affects an estimated 8 to 10
Yves Jackson et al.
BMC infectious diseases, 13, 85-85 (2013-02-15)
With declining vectorial transmission, Chagas disease predominantly affects adults nowadays. The efficacy of nifurtimox in the chronic phase in adult patients is poorly known, particularly in regions where there is no risk of reinfection. Recommendations for treatment outcome assessment rely
The anti-protozoan drug nifurtimox preferentially inhibits clonogenic tumor cells under hypoxic conditions
Li Q, et al.
American Journal of Cancer Research, 7(5), 1084-1084 (2017)
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