N0636

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

• Sinonimo/i: Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• Formula empirica (notazione di Hill): C₆H₆N₂O
• Numero CAS: 98-92-0
• Peso molecolare: 122.12
• Beilstein: 383619
• Numero CE: 202-713-4
• Numero MDL: MFCD00006395
• Codice UNSPSC: 12352205
• ID PubChem: 24897434
• NACRES: NA.75

Proprietà

• Origine biologica: synthetic (organic)
• Nome Commerciale: BioReagent
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• PM: M_w 122.12 g/mol
• tecniche: cell culture | insect: suitable; cell culture | mammalian: suitable
• Colore: white
• Punto di fusione: 128-131 °C (lit.)
• Solubilità: water: soluble 50 mg/mL, clear, colorless
• Stringa SMILE: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9); DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Informazioni sul gene: human ... PARP1(142) , SIRT2(22933)

Descrizione

Descrizione generale

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Applicazioni

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Azioni biochim/fisiol

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319
• Consigli di prudenza: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 302.0 °F - closed cup
• Punto d’infiammabilità (°C): 150 °C - closed cup
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves