Passa al contenuto
Merck
Tutte le immagini(3)

Documenti fondamentali

Visualizza tutta la documentazione

N0636

Sigma-Aldrich

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinonimo/i:

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(3)

About This Item

Formula empirica (notazione di Hill):
C6H6N2O
Numero CAS:
98-92-0
Peso molecolare:
122.12
Beilstein:
383619
Numero CE:
202-713-4
Numero MDL:
MFCD00006395
Codice UNSPSC:
12352205
ID PubChem:
24897434
NACRES:
NA.75

Origine biologica

synthetic (organic)

Livello qualitativo

200

Nome Commerciale

BioReagent

Saggio

≥98% (HPLC)

Stato

powder

PM

Mw 122.12 g/mol

tecniche

cell culture | insect: suitable
cell culture | mammalian: suitable

Colore

white

Punto di fusione

128-131 °C (lit.)

Solubilità

water: soluble 50 mg/mL, clear, colorless

Stringa SMILE

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
DFPAKSUCGFBDDF-UHFFFAOYSA-N

Informazioni sul gene

human ... PARP1(142) , SIRT2(22933)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Applicazioni

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Azioni biochim/fisiol

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

302.0 °F - closed cup

Punto d’infiammabilità (°C)

150 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
SLCK2432
SLCK2314
SLCH7071
SLCF7687
SLCG5682

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Gastrin I human ≥95% (HPLC), powder

Sigma-Aldrich

G9020

Gastrin I human

Nicotinamide (Vitamin B3) solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-016

Nicotinamide (Vitamin B3) solution

Nicotinamide British Pharmacopoeia (BP) Reference Standard

BP460

Nicotinamide

N-acetylcysteine amide ≥98% (HPLC)

Sigma-Aldrich

A0737

N-acetylcysteine amide

Collagenasi powder, Suitable for the digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture

Sigma-Aldrich

C9407

Collagenasi

Nicotinamide European Pharmacopoeia (EP) Reference Standard

N0600000

Nicotinamide

Acido nicotinico BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Sigma-Aldrich

N0761

Acido nicotinico

Niacinamide meets USP testing specifications

Sigma-Aldrich

N5535

Niacinamide

Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells
Kijima T, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 73-91 (2019)
Nicotinamide: Mechanism of action and indications in dermatology
Bains P, et al.
Indian Journal of Dermatology, Venereology and Leprology, 84(2), 234-237 (2018)
Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
The influence of nicotinamide on health and disease in the central nervous system
Fricker RA, et al.
International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture
Hosic S, et al.
bioRxiv, 400721-400721 (2018)
Visualizza tutti i documenti correlati

Articoli

Mitochondrial Stress and ROS

Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.