M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Sinonimo/i:
MPO, Peroxidase, myelo
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About This Item
Numero CAS:
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human leucocytes
Livello qualitativo
Stato
lyophilized powder
Attività specifica
≥50 units/mg protein
Solubilità
H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Informazioni sul gene
human ... MPO(4353)
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Descrizione generale
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Applicazioni
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Azioni biochim/fisiol
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Altre note
Lysosomal heme-containing protein.
Definizione di unità
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Stato fisico
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Risultati analitici
Source material tested and found negative for antibody to HIV and for HBSAG.
Inibitore
N° Catalogo
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Substrato
N° Catalogo
Descrizione
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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