H4381

6-Hydroxydopamine hydrochloride

≥97% (titration), powder, neurotoxin

• Sinonimo/i: 2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
• Formula condensata: (HO)₃C₆H₂CH₂CH₂NH₂ · HCl
• Numero CAS: 28094-15-7
• Peso molecolare: 205.64
• Beilstein: 4274007
• Numero CE: 248-837-2
• Numero MDL: MFCD00012895
• Codice UNSPSC: 12352116
• ID PubChem: 24895641
• NACRES: NA.77

Proprietà

• Nome del prodotto: 6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
• Livello qualitativo: 100
• Saggio: ≥97% (titration)
• Stato: powder
• Colore: off-white to brown
• Punto di fusione: 232-233 °C (dec.) (lit.)
• Solubilità: H₂O: >50 mg/mL, clear, yellow to brown
• Temperatura di conservazione: room temp
• Stringa SMILE: Cl.NCCc1cc(O)c(O)cc1O
• InChI: 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H; QLMRJHFAGVFUAC-UHFFFAOYSA-N

Descrizione

Descrizione generale

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

Applicazioni

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

Azioni biochim/fisiol

Neurotoxin that destroys catecholaminergic terminals.

Avvertenza

Hygroscopic

Ricostituzione

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.

Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves