H8502

Dopamine hydrochloride

≥98% (TLC), powder, neurotransmitter

• Sinonimo/i: 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
• Formula condensata: (HO)₂C₆H₃CH₂CH₂NH₂·HCl
• Numero CAS: 62-31-7
• Peso molecolare: 189.64
• Beilstein: 3656720
• Numero CE: 200-527-8
• Numero MDL: MFCD00012898
• Codice UNSPSC: 12352116
• ID PubChem: 24277897
• NACRES: NA.77

Proprietà

• product name: Dopamine hydrochloride,
• Forma fisica: powder
• Livello qualitativo: 200
• Colore: light tan
• Punto di fusione: 248-250 °C (lit.)
• Solubilità: alcohol: 20 mg/mL; H₂O: soluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].NCCc1ccc(O)c(O)c1
• InChI: 1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H; CTENFNNZBMHDDG-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADRB1(153)

Descrizione

Descrizione generale

Dopamine (DA) works as a neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system. It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine. Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis. A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder.

Applicazioni

Dopamine hydrochloride has been used:

• to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei.
• to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
• to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.
• as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase.
• added exogenously to the culture medium to study its effect on H. contortus female worms.

Caratteristiche e vantaggi

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Avvertenza

Light sensitive

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classi di pericolo: Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves