D3900

Desipramine hydrochloride

≥98% (TLC), powder, imipramine metabolite

• Formula empirica (notazione di Hill): C₁₈H₂₂N₂ · HCl
• Numero CAS: 58-28-6
• Peso molecolare: 302.84
• Numero CE: 200-373-1
• Numero MDL: MFCD00058108
• Codice UNSPSC: 12352116
• ID PubChem: 24278094
• NACRES: NA.77

Proprietà

• Nome del prodotto: Desipramine hydrochloride, ≥98% (TLC), powder
• Saggio: ≥98% (TLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: H₂O: 50 mg/mL
• Ideatore: Sanofi Aventis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H; XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Informazioni sul gene: human ... SLC6A2(6530)

Descrizione

Descrizione generale

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.

Applicazioni

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
• to protect unselective damage to the noradrenergic system
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Azioni biochim/fisiol

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H317,H319,H334,H335
• Consigli di prudenza: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves