27840

Corticosterone

≥98.5% (HPLC)

• Sinonimo/i: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Formula empirica (notazione di Hill): C₂₁H₃₀O₄
• Numero CAS: 50-22-6
• Peso molecolare: 346.46
• Beilstein: 2339601
• Numero CE: 200-019-6
• Numero MDL: MFCD00037715
• Codice UNSPSC: 12352211
• ID PubChem: 57648276
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥98.5% (HPLC)
• Forma fisica: powder or crystals
• Attività ottica: [α]20/D +223±3°, c = 1% in ethanol
• Punto di fusione: 179-183 °C (lit.); 179-183 °C
• Gruppo funzionale: ketone
• Stringa SMILE: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1; OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Informazioni sul gene: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descrizione

Descrizione generale

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Applicazioni

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Azioni biochim/fisiol

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota sulla preparazione

Corticosterone is soluble in chloroform and ethanol.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves