C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Sinonimo/i: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Formula empirica (notazione di Hill): C₂₁H₃₀O₄
• Numero CAS: 50-22-6
• Peso molecolare: 346.46
• Beilstein: 2339601
• Numero CE: 200-019-6
• Numero MDL: MFCD00037715
• Codice UNSPSC: 51111800
• ID PubChem: 24278302
• NACRES: NA.77

Proprietà

• product name: Corticosterone, ≥92%
• Origine biologica: synthetic (organic)
• Saggio: ≥92%
• Forma fisica: powder
• Punto di fusione: 179-183 °C (lit.)
• Solubilità: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1; OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Informazioni sul gene: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descrizione

Applicazioni

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Azioni biochim/fisiol

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves