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GW10072F

Sigma-Aldrich

Anti-C-Reactive Protein antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-CRP

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About This Item

Numero MDL:
MFCD00162183
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-10072F

tecniche

indirect ELISA: suitable
western blot: suitable

N° accesso NCBI

CAA40020.1

N° accesso UniProt

P02741

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CRP(1401)

Descrizione generale

C-reactive protein (CRP) is a member of a protein family that serve as soluble pattern recognition molecules. This protein is generated and liberated in the circulation in response to infection and tissue damage. CRP gene is located on human chromosome 1q23.2.
CRP is synthesized by human peripheral blood mononuclear cells. The CRP gene is localized to chromosome 1.

Immunogeno

C-reactive protein.
Immunogen Sequence: GI # 30213, sequence 1-224

Applicazioni

Anti-C-Reactive Protein antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

Azioni biochim/fisiol

C-Reactive Protein (CRP) is a homopentamer that belongs to the pentaxin family. CRP binds to phosphorylcholine in a calcium dependent manner and plays a key role in host defense. It is involved in several defense mechanisms such as, agglutination, bacterial capsular swelling, phagocytosis and complement fixation. CRP interacts with secreted M-ficolin anchored to monocyte transmembrane G protein-coupled receptor 43 and mediates immune signaling and regulates host defense. It scavenges nuclear waste that is released from cells following apoptosis.
C-reactive protein (CRP) plays a major role the early stages of atherosclerosis and pantothenic acid (PA). It shows an antioxidant effect in inflammatory process. The active monomeric form of C-reactive protein (CRP) is involved in proinflammatory functions.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
039K1992
029K2178

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S Danese et al.
Alimentary pharmacology & therapeutics, 34(1), 1-10 (2011-05-05)
The addition of antitumour necrosis factor-α (TNF-α) agents to the therapeutic armamentarium against Crohn's disease has been a revolution in its management. However, approximately 25 to 40% of patients who initially benefit from anti-TNF-α treatment develop intolerable adverse events or
Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.
Shih PB, et al.
The Journal of Rheumatology, 35(11), 2171-2178 (2008)
Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabor rupture of membranes.
Musilova I, et al.
PLoS ONE, 12(8), e0182731-e0182731 (2017)
The long-term relationship between dietary pantothenic acid (vitamin B5) intake and C-reactive protein concentration in adults aged 40 years and older.
Jung S, et al.
Nutrition, Metabolism, and Cardiovascular Diseases, 27(9), 806-816 (2017)
An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein.
Li HY, et al.
The Journal of Biological Chemistry, 291(16), 8795-8804 (2016)
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