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Documenti fondamentali

C1688

Sigma-Aldrich

Monoclonal Anti-C-Reactive Protein antibody produced in mouse

clone CRP-8, ascites fluid

Sinonimo/i:

Anti-CRP

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

ascites fluid

Tipo di anticorpo

primary antibodies

Clone

CRP-8, monoclonal

PM

antigen 24 kDa

contiene

15 mM sodium azide

Reattività contro le specie

human

tecniche

dot blot: suitable
indirect ELISA: 1:40,000
western blot: 1:200

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CRP(1401)

Categorie correlate

Descrizione generale

C-reactive protein (CRP) is a member of the pentraxin family of proteins and synthesized by the liver. It is also known as PTX1. The CRP gene is mapped to human chromosome 1q23.2.

Specificità

The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α1-acid glycoprotein, human IgG, and CRP from Limulus.

Immunogeno

human C-reactive protein.

Applicazioni

  • It has been used in immunoblotting assay, to identify monomeric CRP.
  • In time-resolved fluorometric assay.
Monoclonal Anti-C-Reactive Protein antibody produced in mouse is suitable for the following:
  • dot blot analysis
  • indirect ELISA at a working dilution of 1:40,000
  • western blotting at a working dilution of 1:200

Azioni biochim/fisiol

C-reactive protein (CRP) shows essential scavenging and metabolic activity and is also associated with defence mechanism. It activates the complement pathway by binding to calcium-dependent exogenous and autologous molecules containing phosphocholine (PC). It may have pathogenic effects and is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). The CRP diagnostic value is higher for acute pyelonephritis than lower urinary tract infection. Thus, it helps in differentiating between upper and lower urinary tract infection. It is considered best for predicting the risk of cardiovascular disease..

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo.
Sato A, et al.
European Journal of Pharmacology, 745, 46-51 (2014)
Aleksandra N Klisic et al.
Laboratory medicine, 45(1), 12-16 (2014-04-12)
Although C-reactive protein (CRP) is among the best cardiovascular disease risk predictors, data regarding the association of CRP and menopause are controversial. In this study, we measured CRP by a high-sensitivity method (hsCRP), cholesterol, lipoproteins, and triglycerides in normal and
Birgit Fendl et al.
Scientific reports, 11(1), 6996-6996 (2021-03-28)
There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP (pCRP) into its structural isoform pCRP* and into monomeric CRP (mCRP). This conversion can occur on the membranes of apoptotic
Rui-Ying Xu et al.
BMC urology, 14, 45-45 (2014-06-03)
Urinary infections are a common type of pediatric disease, and their treatment and prognosis are closely correlated with infection location. Common clinical manifestations and laboratory tests are insufficient to differentiate between acute pyelonephritis and lower urinary tract infection. This study
Akiyoshi Kinoshita et al.
Oncology, 86(5-6), 308-317 (2014-06-14)
C-reactive protein (CRP) is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). We investigated the prognostic value of adding the CRP level to other validated staging systems (Cancer Liver Italian Program, Japan Integrated Staging, Barcelona Clinic Liver Cancer

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