E6405
Anti-Endothelial Cell Protein C Receptor antibody, Rat monoclonal
clone RCR-379, purified from hybridoma cell culture
Sinonimo/i:
Anti-EPCR, Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat
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About This Item
Prodotti consigliati
Origine biologica
rat
Coniugato
unconjugated
Forma dell’anticorpo
purified from hybridoma cell culture
Tipo di anticorpo
primary antibodies
Clone
RCR-379, monoclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
human
tecniche
flow cytometry: 5-20 μg/mL using HUVEC cells
Isotipo
IgG2a
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... PROCR(10544)
Descrizione generale
Monoclonal Anti-endothelial cell protein C receptor (EPCR) (rat IgG2a isotype) is derived from the RCR379 hybridoma produced by the fusion of mouse SP2/0 myeloma cells and lymphatic cells isolated from the superficial inguinal lymph nodes from Wister rats immunized with human EPCR-positive RE-1 cells. Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor), is a protein encoded by the PROCR gene in humans and is mapped to the locus 20q11.22. EPCR is a type 1 transmembrane glycoprotein containing two domains in the extracellular region that are homologous to the α1 and α2 domains of CD1/ major histocompatibility complex class 1 (MHC) class 1 molecules. It is expressed exclusively in endothelial cells and small vessels such as capillaries of the alveolar wall in the lung.
Specificità
Monoclonal Anti-Endothelial Cell Protein C Receptor (EPCR) recognizes human EPCR (49 kDa).
Immunogeno
human EPCR-positive RE-1 cells.
Applicazioni
Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat is suitable for flow cytometry at a concentration of 5-20μg/mL using HUVEC cells.
Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat may be used in immunohistochemistry.
Azioni biochim/fisiol
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. EPCR is a member of the CD1/major histocompatibility complex superfamily and plays an important role in regulating the inflammatory response. It is also identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes. EPCR is associated with an increased risk of venous thromboembolism (VTE).
The EPCR protein also performs other functions, like binding to proteinase. The complex then binds to macrophage 1 antigen (MAC-1) on activated neutrophils and inhibits their adhesion to activated endothelium
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Stoccaggio e stabilità
For continuous use, store at 2-8 °C for up to one month. For prolonged storage, freeze in working aliquots at −20 °C. Repeated freezing and thawing is not recom-mended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Vaheh Oganesyan et al.
The Journal of biological chemistry, 277(28), 24851-24854 (2002-05-30)
The endothelial cell protein C receptor (EPCR) shares approximately 20% sequence identity with the major histocompatibility complex class 1/CD1 family of molecules, accelerates the thrombin-thrombomodulin-dependent generation of activated protein C, a natural anticoagulant, binds to activated neutrophils, and can undergo
Alice G Vassiliou et al.
Intensive care medicine, 39(10), 1752-1759 (2013-07-25)
Endothelial protein C receptor (EPCR) is expressed mainly in endothelial cells and is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. We assessed whether haplotypes in the EPCR gene modify the risk of severe sepsis and/or
P Medina et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 684-690 (2014-01-18)
To confirm the effect of the endothelial protein receptor gene (PROCR) haplotypes H1 and H3 on venous thromboembolism (VTE), to study their effect on endothelial protein C receptor (EPCR) expression in human umbilical vein endothelial cells, and to investigate the
Izumi Naka et al.
Malaria journal, 13, 105-105 (2014-03-19)
Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor
Z Laszik et al.
Circulation, 96(10), 3633-3640 (1997-12-13)
The protein C anticoagulant pathway is critical to the control of hemostasis. Thrombomodulin and a newly identified receptor for protein C/activated protein C, EPCR, are both present on endothelium. EPCR augments activation of protein C by the thrombin-thrombomodulin complex. To
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