D8174

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α

≥98% (HPLC), solution, thromboxane A2 agonist

• Sinonimo/i: U-46619, U46619
• Formula empirica (notazione di Hill): C₂₁H₃₄O₄
• Numero CAS: 56985-40-1
• Peso molecolare: 350.49
• Beilstein: 4267334
• Numero MDL: MFCD00135238
• Codice UNSPSC: 12352211
• ID PubChem: 24894197
• NACRES: NA.77

Proprietà

• product name: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α, solution, 10 mg/mL in methyl acetate
• Forma fisica: solution
• Livello qualitativo: 200
• Concentrazione: 10 mg/mL in methyl acetate
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
• InChI: 1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1; LQANGKSBLPMBTJ-REGKDVDGSA-N

Descrizione

Descrizione generale

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is an endoperoxide/thromboxane analog.

Applicazioni

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α has been used:

• to induce aortic smooth muscle (SM) contraction in mice deficient in myosin light chain 9 (Myl9) gene
• to induce contraction as part of vascular reactivity experiments using mice aorta
• as a thromboxane/prostaglandin agonist to study the effect of dithiothreitol (DTT) on mice arterial vessel viability

Azioni biochim/fisiol

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is a thromboxane A2 agonist. It is useful in in vitro experiments to induce shape change, aggregation, secretion, phosphoinositide hydrolysis, and protein phosphorylation in platelets. It also causes an elevation in the cytosolic Ca⁺⁺ levels slightly affecting the cyclic adenosine monophosphate (cAMP) formation. It acts as a potent stimulator of vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte adhesion to the endothelium.

Caratteristiche e vantaggi

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H319,H336
• Consigli di prudenza: P210 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Rischi supp: EUH066
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 14.0 °F
• Punto d’infiammabilità (°C): -10 °C
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter