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Key Documents

D4001

Sigma-Aldrich

2′-Deoxyuridine 5′-triphosphate sodium salt

≥95%

Sinonimo/i:

dUTP sodium salt

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About This Item

Formula empirica (notazione di Hill):
C9H15N2O14P3 · xNa+
Numero CAS:
Peso molecolare:
468.14 (free acid basis)
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51

Origine biologica

synthetic (organic)

Saggio

≥95%

Forma fisica

powder

Temperatura di conservazione

−20°C

Stringa SMILE

[Na].OC1CC(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O14P3.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17);;
FVFWWPFKJNTHIQ-UHFFFAOYSA-N

Applicazioni

2′-Deoxyuridine 5′-triphosphate (dUTP) may be used to study the distribution, specificity and kinetics of deoxyuridine 5′-triphosphate nucleotidohydrolase(s) (dUTPase, EC 3.6.1.23). dUTPase are important enzymes that protect cells from the incorporation of dUTP into DNA.dUTP is a component of the TUNEL (terminal deoxyribonucleotidyl-transferase-(TdT)-mediated deoxyuridine-5′-triphosphate- (dUTP) nick-end labeling) test. TUNEL is a common method for detecting DNA fragmentation that results from apoptotic signaling cascades.
2′-Deoxyuridine 5′-triphosphate sodium salt has been used in the extraction of white muscles from the African catfish.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Lucy Freeman et al.
The Journal of biological chemistry, 284(37), 25280-25289 (2009-07-10)
Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous enzymes essential for hydrolysis of dUTP, thus preventing its incorporation into DNA. Although Epstein-Barr virus (EBV) dUTPase is monomeric, it has a high degree of similarity with the more frequent trimeric form of the
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