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Key Documents

B2754

Sigma-Aldrich

Betaine monohydrate

≥99%

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About This Item

Formula condensata:
(CH3)3N+CH2COO- · H2O
Numero CAS:
Peso molecolare:
135.16
Beilstein:
3626258
Numero CE:
Numero MDL:
Codice UNSPSC:
12352204
ID PubChem:
NACRES:
NA.83

Origine biologica

synthetic

Livello qualitativo

Saggio

≥99%

Forma fisica

powder or crystals

Solubilità

water: 50 mg/mL, clear, colorless

Temperatura di conservazione

2-8°C

Stringa SMILE

O.C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2.H2O/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H2
NJZRLXNBGZBREL-UHFFFAOYSA-N

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Descrizione generale

Betaine is a zwitterionic quaternary ammonium compound and is mainly present in animals, microorganisms and plants. It is one of the main constituent of several food items like wheat, shellfish, spinach and sugar beets. It is also termed as trimethylglycine, lycine, glycine betaine and oxyneurine. Betaine is a methyl derivative of glycine. It has a molecular mass of 117.2.

Applicazioni

Betaine monohydrate has been used:
  • in the preparation of KLA buffer to perform polymerase chain reaction (PCR)
  • to study the its effects on Km and Vmax of human aldose reductase
  • to study its effects on the growth of A549 lung cancer both in vitro and in vivo

Azioni biochim/fisiol

Betaine, as an osmolyte helps to guard the cells, proteins and enzymes from environmental stress. It also acts as a methyl donor to involve in the methionine cycle.
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Study of the effects of betaine and/or C-phycocyanin on the growth of lung cancer A549 cells in vitro and in vivo
Bingula R, et al.
Journal of Oncology, 2016 (2016)
Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis.
Surendran K, et al.
Journal of the American Society of Nephrology, 16(8), 2373-2384 (2005)
Factors affecting counteraction by methylamines of urea effects on aldose reductase
Burg MB, et al.
Proceedings of the National Academy of Sciences of the USA, 96(11), 6517-6522 (1999)
Stuart A S Craig
The American journal of clinical nutrition, 80(3), 539-549 (2004-08-24)
Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary sources include seafood, especially marine invertebrates ( approximately 1%); wheat germ or bran ( approximately 1%); and spinach ( approximately 0.7%). The principal physiologic role of betaine is
Scott O Sundberg et al.
Clinical chemistry, 60(10), 1306-1313 (2014-08-15)
Clinical molecular testing typically batches samples to minimize costs or uses multiplex lab-on-a-chip disposables to analyze a few targets. In genetics, multiple variants need to be analyzed, and different work flows that rapidly analyze multiple loci in a few targets

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