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Key Documents

PHR1293

Supelco

Nimodipine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

Nimodipine, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

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About This Item

Formula empirica (notazione di Hill):
C21H26N2O7
Numero CAS:
Peso molecolare:
418.44
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to BP 651
traceable to Ph. Eur. N0850000
traceable to USP 1463858

Famiglia di API

nimodipine

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C

InChI

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
UIAGMCDKSXEBJQ-UHFFFAOYSA-N

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Descrizione generale

Nimodipine is a well-known calcium antagonist and is a moderate cerebral vasodilator, in addition to being an inhibitor of cerebrovascular reactivity. It is suggested to be cytoprotective by causing a decrease in the influx of calcium into the nerve cells. It is accepted for use in the management of delayed ischaemic dysfunction and is commonlly used in the studies of brain function impairment and dementia in old age.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Nimodipine can be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by various electrochemical and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA0583 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Metiliparaben

The atomic absorption spectrophotometric method for indirect determination of nimodipine in tablets
Canlica M and Islimyeli S
Turkish Journal of Chemistry, 29(2), 141-146 (2005)
Facile spectrophotometric determination of nimodipine and nitrazepam in pharmaceutical preparations
Revanasiddappa HD, et al.
Analele Universitatii Bucuresti: Chimie , 20(1), 189-196 (2011)
Enantiospecific determination of nimodipine in human plasma by liquid chromatography-tandem mass spectrometry
Muck WM
Journal of Chromatography A, 712(1), 45-53 (1995)
Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.
Pickard JD, et al.
BMJ (Clinical Research ed.), 298(6674), 636-642 (1989)
Assay of nimodipine-an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry
Gupta VK, et al.
International Journal of Electrochemical Science, 6(1), 37-51 (2011)

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