N1636

β-Dinucleotide nicotinamide adenina

purified by column chromatography, ≥99%

• Sinonimo/i: β-DPN, β-NAD, Coenzima 1, Cozimasi, DPN, NAD, Nadide, Nucleotide difosfopiridina
• Formula empirica (notazione di Hill): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
• Numero CAS: 53-84-9
• Peso molecolare: 663.43 (anhydrous basis)
• Numero CE: 200-184-4
• Numero MDL: MFCD00036253
• Codice UNSPSC: 41106305
• eCl@ss: 39200202
• ID PubChem: 24897510
• NACRES: NA.55

Proprietà

• Livello qualitativo: 200
• Saggio: ≥99%
• Forma fisica: crystalline powder
• Colore: white
• Temperatura di conservazione: −20°C
• Stringa SMILE: NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1; BAWFJGJZGIEFAR-NNYOXOHSSA-N

Descrizione

Descrizione generale

β-Nicotinamide adenine dinucleotide (NAD) is an electron carrier and a cofactor. It is ubiquitously found in the living system. NAD⁺ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD⁺ complexes, the enzyme-cofactor interactions are highly conserved.

Applicazioni

β-Nicotinamide adenine dinucleotide hydrate has been used:

• to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)
• in the reaction buffer for pyruvate kinase (PK) activity assay
• as a component of master mix for a high throughput screening

Azioni biochim/fisiol

β-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD⁺⁾ and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. It significantly participates in enzyme-catalyzed oxido-reduction processes and many genetic processes. It is also involved in microbial catabolism.

Accettore di elettroni

Confezionamento

Confezionato in base al peso solido.

Altre note

Crystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperatures than amorphous NAD.

Questa è la forma comune del NAD.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)