Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

11126

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate

puriss., meets analytical specification of USP, 99.0-103.0%, powder

Sinonimo/i:

Antimony potassium tartrate trihydrate, Tartar emetic

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C8H4K2O12Sb2 · 3H2O
Numero CAS:
28300-74-5
Peso molecolare:
667.87
Numero CE:
234-293-3
Numero MDL:
MFCD00167056
Codice UNSPSC:
12352100
ID PubChem:
57646885
NACRES:
NA.21

Grado

puriss.

Livello qualitativo

200

Saggio

99.0-103.0%

Forma fisica

powder

Qualità

meets analytical specification of USP

Impurezze

≤0.02 mmol/g free acid
≤0.02 mmol/g free alkali

Perdita

≤2.7% loss on drying, 105 °C

Punto di fusione

≥300 °C (lit.)

Cationi in tracce

As: ≤150 mg/kg
Pb: ≤20 mg/kg

Stringa SMILE

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
WBTCZEPSIIFINA-UHFFFAOYSA-J

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Categorie correlate

Descrizione generale

Potassium antimonyl tartrate trihydrate is a trivalent antimonial compound. It has been reported to be more toxic than pentavalent antimony (Pentostam) against Leishmania species. Its crystal structure has been investigated by the three-dimensional X-ray and white radiation neutron diffraction techniques. It crystallizes in space group C2221. Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Applicazioni

Potassium antimonyl tartrate trihydrate was employed as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum†
It may also be used as a standard solution to determine the metalloid concentration such as Sb(III) and Sb(V) in surface soil, using high performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H301,H315,H317,H332,H411

Classi di pericolo

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BCCG6808
BCCG6346
BCCG2737
BCCC8607
BCBZ5634

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

Blu di metilene purum p.a., for microscopy (Bact., Bot., Hist., Vit.), ≥97.0% (calc. based on dry substance, AT)

Sigma-Aldrich

66720

Blu di metilene

Ammonium molybdate tetrahydrate ACS reagent, 99.98% trace metals basis

Sigma-Aldrich

431346

Ammonium molybdate tetrahydrate

Fosfato di potassio ACS reagent, ≥99.0%

Sigma-Aldrich

P0662

Fosfato di potassio

Acido L-ascorbico suitable for cell culture, suitable for plant cell culture, ≥98%

Sigma-Aldrich

A4544

Acido L-ascorbico

Potassium hexahydroxoantimonate(V)

Sigma-Aldrich

P4308

Potassium hexahydroxoantimonate(V)

Acido solforico ACS reagent, 95.0-98.0%

Sigma-Aldrich

258105

Acido solforico

"A study of antimony complexed to soil-derived humic acids and inorganic antimony species along a Massachusetts highway"
Ceriotti G and Amarasiriwardena D
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 91(01), 85-93 (2009)
D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
Susan Wyllie et al.
Biochemical pharmacology, 71(3), 257-267 (2005-12-02)
Trivalent antimonial compounds (Sb(III)), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukaemia (APL). Here, we examine the effects of Sb(III) and pentavalent antimonial drugs (Sb(V)) on glutathione homeostasis, oxidative
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.