MABS1882

Anti-TAOK3 Antibody, clone 1H9.1

clone 1H9.1, from mouse

• Sinonimo/i: Serine/threonine-protein kinase TAO3, EC:2.7.11.1, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, JIK, Kinase from
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 1H9.1, monoclonal
• Reattività contro le specie: mouse, human
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotipo: IgG2aκ
• N° accesso NCBI: NP_057365
• N° accesso UniProt: Q9H2K8
• Condizioni di spedizione: ambient
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TAOK3(51347)

Descrizione

Descrizione generale

Serine/threonine-protein kinase TAO3 (UniProt: Q9H2K8; also known as EC:2.7.11.1, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, JIK, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3) is encoded by the TAOK3 (also known as DPK, JIK, KDS, MAP3K18) gene (Gene ID: 51347) in human. TAO kinase 3 is a member of the STE20 subfamily of the STE Ser/Thr protein kinases. It is a serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage at the G2/M phase, it is phosphorylated at Ser324 by ATM and acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. It is shown to inhibit basal activity of MAPK8/JNK cascade and also diminishes its activation in response epidermal growth factor. TAO kinase 3 is highly expressed in peripheral blood leukocytes, thymus, spleen, kidney, skeletal muscle, heart, and liver.

Specificità

Clone 1H9.1 specifically detects Serine/threonine-protein kinase TAO3 (TAOK3) in K562 cells. It targets an epitope of 16 amino acids in the C-terminal region.

Immunogeno

KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminus end of human Serine/threonine-protein kinase TAO3 (TAOK3).

Applicazioni

Detect TAOK3 using this mouse monoclonal Anti-TAOK3 Antibody, clone 1H9.1, Cat. No. MABS1882. It has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TAOK3 in human testis, human small intestine, and human pancreas.

Western Blotting Analysis: 0.5 µg/mL from a representative lot detected TAOK3 in 10 µg of Raw264.7 cell lysate.

Research Category
Signaling

Qualità

Evaluated by Western Blotting in K562 cells.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TAOK3 in 10 µg of K562 cell lysate.

Descrizione del bersaglio

~120 kDa observed, 105.41 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Stato fisico

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1