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Key Documents

AB5847

Sigma-Aldrich

Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

Chemicon®, from rabbit

Sinonimo/i:

GluR1

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Confezionamento

antibody small pack of 25 μL

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GRIA1(2890)

Specificità

Recognizes Glutamate Receptor 1 [GluR1], phosphoSer831. The antibody recognizes a protein of ~100 kDa corresponding to GluR1 phosphorylated at Ser831 in rat hippocampal homogenate. Immunolabeling of the GluR1 protein is blocked by the immunogen peptide but not by the corresponding non-phosphopeptide. The immunogen sequence is 100% homologous in human and mouse.

Immunogeno

Epitope: phosphoSer 831
Synthetic peptide corresponding to amino acids surrounding the phosphoSer831 of rat GluR1.

Applicazioni

Detect Glutamate Receptor 1 using this Anti-Glutamate Receptor 1 Antibody, phosphoSer 831 validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot and dot blots: 1:500-1:1000. The working dilution should be based on the tissue and the expected phosphorylation state.

Optimal working dilutions must be determined by the end user.

Descrizione del bersaglio

100 kDa

Linkage

Replaces: 05-823

Stato fisico

Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
ImmunoAffinity Purified

Stoccaggio e stabilità

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Hippocampal neurons, rat brain tissue lysates or mouse brain tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Marion Rame et al.
PloS one, 12(5), e0177036-e0177036 (2017-05-05)
Single sub-anesthetic doses of ketamine can exacerbate the symptoms of patients diagnosed with schizophrenia, yet similar ketamine treatments rapidly reduce depressive symptoms in major depression. Acute doses of the atypical antipsychotic drug clozapine have also been shown to counteract ketamine-induced
Mónica Fernández-Monreal et al.
Journal of cell science, 129(14), 2793-2803 (2016-06-04)
Hippocampal synaptic plasticity involves both membrane trafficking events and intracellular signaling, but how these are coordinated is far from clear. The endosomal transport of glutamate receptors in and out of the postsynaptic membrane responds to multiple signaling cascades triggered by
Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.
Shukla, K; Kim, J; Blundell, J; Powell, CM
The Journal of Biological Chemistry null
Caitlin E Burgdorf et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11894-11911 (2017-11-02)
Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of learning, reduces cocaine-seeking behavior; however, the molecular mechanisms underlying this process remain largely unknown. We report that extinction, but not
Svetlana Korotchenko et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369(1654), 20140134-20140134 (2014-09-17)
Heparan sulfates (HSs) are complex and highly active molecules that are required for synaptogenesis and long-term potentiation. A deficit in HSs leads to autistic phenotype in mice. Here, we investigated the long-term effect of heparinase I, which digests highly sulfated

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