582231

Tetanus Toxoid

from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem^®

• Sinonimo/i: TTx
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.
• Livello qualitativo: 200
• Stato: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.

Applicazioni

Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay

Azioni biochim/fisiol

Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.

Caratteristiche e vantaggi

• Prepared by formaldehyde inactivation of tetanus toxin.
• Prepared by formaldehyde inactivation of tetanus toxin.
• Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
• Cell permeable: no
• Product does not compete with ATP.
• Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.

Ricostituzione

Reconstitute in 50 µl of sterile distilled H₂O

Altre note

Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable