582243

Tetanus Toxin, Clostridium tetani

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Forma fisica: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Disponibilità: not available in Canada,
• Condizioni di stoccaggio: OK to freeze
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.

Produced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

Azioni biochim/fisiol

Binds G_T1b ganglioside in a hemagglutination assay

Primary Target
Tetanus toxin is one of the deadliest toxins known

Product does not compete with ATP.

Attenzione

Toxicity: Highly Toxic (H)

Ricostituzione

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Please refer to the vial label for lot-specific reconstitution volume.

Risultati analitici

Single band by SDS-PAGE

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H330,H370
• Consigli di prudenza: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3