14-306-M
GSK3β Protein, active, 10 µg
Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
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About This Item
Codice UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.26
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in baculovirus infected Sf21 cells
Stato
liquid
PM
Mw 51 kDa
Composizione
mercaptoethanol, 0.1-1%
saccharose, 5-10%
Produttore/marchio commerciale
Upstate®
Condizioni di stoccaggio
(Tightly closed)
tecniche
activity assay: suitable (kinase)
Solubilità
water: soluble
N° accesso NCBI
N° accesso UniProt
Informazioni sul gene
human ... GSK3B(2932)
Descrizione generale
Glycogen synthase kinase 3β (GSK3β) is a serine-threonine kinase that is present in most eukaryotes. The GSK3β gene is located on the human chromosome at 3q13.3. GSK3β is made up of an N-terminal β-sheet domain that is coupled to the C-terminal α-helical domain.
Research area: Cell Signaling
Research area: Cell Signaling
Azioni biochim/fisiol
Glycogen synthase kinase 3β (GSK3β) regulates glycogen metabolism via an insulin-dependent pathway. It participates in many signaling pathways including cellular processes such as cell cycle, cell proliferation, and inflammation. GSK3β mediated-negative regulation of insulin signaling pathway leads to type 2 diabetes. GSK3β functions as a tumor suppressor that represses neoplastic transformation in cells. It is an essential regulator of the Wnt/β-catenin signaling pathway. Abnormal regulation of GSK3β is associated with cardiovascular disease, bipolar disorder, and neurodegenerative diseases.
Confezionamento
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-306M when ordering the 250μg size.
Qualità
Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2
Altre note
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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Xu, J., et al
The Journal of Biological Chemistry, 278, 26929-26937 (2003)
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
Sutherland, C and Cohen, P
Febs Letters, 338, 37-42 (1994)
rystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Dajani R, et al.
Cell, 105(6), 721-732 (2009)
Regulation and functions of the glycogen synthase kinase-3 subfamily.
Woodgett, J R
Seminars in cancer biology, 5, 269-275 (1994)
Mark S Wainwright et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(10), 6233-6238 (2003-05-06)
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