12-533
GSM (GSK3 substrate peptide)
Sinonimo/i:
GSK3 Substrate Peptide, GSM Peptide, Substrate for GSK3
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About This Item
Codice UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.41
Prodotti consigliati
PM
Mw 2673 Da
Livello qualitativo
Produttore/marchio commerciale
Upstate®
tecniche
activity assay: suitable (kinase)
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Applicazioni
GSM (GSK3 substrate peptide) has been used:
- in in vitro glycogen synthase kinase 3 (GSK-3)-3β activity assay to measure the kinase activity of GSK-3
- as a supplement in perfusates in kinase activity assay to determine the effect of the phosphatase-activating domain (PAD) peptide on squid axoplasm
- as a control in Kinase-Glo luminescent kinase assay to measure the influence of ibuprofen treatment on the catalytic activity of the kinase GSK3β
Azioni biochim/fisiol
Glycogen synthase kinase 3 (GSK3) is a protein kinase, which regulates glycogen metabolism. It regulates various cell functions, like signaling by insulin, growth factors and nutrients, and the specification of cell fates during embryonic development. GSK3 is involved modulating in apoptosis, cell division, and microtubule function.
Qualità
Routinely evaluated as a substrate for GSK3β (Catalog # 14-306).
Stato fisico
1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.
Stoccaggio e stabilità
Lyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
Ryves, W. J., et al
Analytical biochemistry, 264, 124-127 (1998)
Nydia Tejeda-Muñoz et al.
Molecular and cellular biology, 36(5), 731-741 (2015-12-30)
The molecular events that drive Wnt-induced regulation of glycogen synthase kinase 3β (GSK-3β) activity are poorly defined. In this study, we found that protein kinase Cζ (PKCζ) and GSK-3β interact mainly in colon cancer cells. Wnt stimulation induced a rapid
P Cohen et al.
Nature reviews. Molecular cell biology, 2(10), 769-776 (2001-10-05)
Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has
W Jonathan Ryves et al.
Biochemical and biophysical research communications, 290(3), 967-972 (2002-01-19)
Lithium inhibits (Li(+)) glycogen synthase kinase-3 (GSK-3) by competition for magnesium (Mg(2+)), but not ATP or substrate. Here, we show that the group II metal ion beryllium (Be(2+)) is a potent inhibitor of GSK-3 and competes for both Mg(2+) and
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