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Key Documents

Altri documenti

K3888

Sigma-Aldrich

Kenpaullone

≥98%

Sinonimo/i:

9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one, NSC 664704

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About This Item

Formula empirica (notazione di Hill):
C16H11BrN2O
Numero CAS:
142273-20-9
Peso molecolare:
327.18
Numero MDL:
MFCD02683595
Codice UNSPSC:
12352200
ID PubChem:
24278507

Livello qualitativo

100

Saggio

≥98%

Forma fisica

solid

Colore

yellow

Solubilità

DMSO: 18 mg/mL, clear, yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI

1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
QQUXFYAWXPMDOE-UHFFFAOYSA-N

Informazioni sul gene

human ... CDC2(983)
mouse ... Gsk3b(56637)
rat ... Gsk3b(84027)

Applicazioni

Kenpaullone has been used:
  • as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
  • as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
  • as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

Azioni biochim/fisiol

Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.

Caratteristiche e vantaggi

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Store under argon

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Roscovitine ≥98% (TLC)

Sigma-Aldrich

R7772

Roscovitine

RO-3306 ≥98% (HPLC)

Sigma-Aldrich

SML0569

RO-3306

Alsterpaullone A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC₅₀ = 4 nM) and Cdk1/cyclin B (IC₅₀ = 35 nM).

Sigma-Aldrich

126870

Alsterpaullone

Ken-ichiro Nakajima et al.
Nature communications, 7, 10268-10268 (2016-01-09)
Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling
Tomohiro Kitabayashi et al.
Scientific reports, 9(1), 10049-10049 (2019-07-13)
Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors, including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug treatment for GBM, GBM cells acquire resistance and become refractory to TMZ during treatment. Therefore, glioma
Nicolas O Fortunel et al.
Nature biomedical engineering, 3(12), 985-997 (2019-10-23)
Expanded autologous skin keratinocytes are currently used in cutaneous cell therapy, and embryonic-stem-cell-derived keratinocytes could become a complementary alternative. Regardless of keratinocyte provenance, for efficient therapy it is necessary to preserve immature keratinocyte precursors during cell expansion and graft processing.
B J Carroll
Advances in biochemical psychopharmacology, 39, 179-188 (1984-01-01)
The DST is a practical laboratory test that can be used in outpatient or inpatient settings. The required laboratory technology is available at any hospital. No subjective, behavioral, or metabolic side-effects occur with the single-dose administration of dexamethasone, and the
Mark Y Fang et al.
Neuron, 103(5), 802-819 (2019-07-06)
Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To yield insights into the role of SGs in pathophysiology, we performed a high-content screen to identify small
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