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Key Documents

C-165

Supelco

Creatinine-D3 solution

100 μg/mL ((50:50) MeOH:Water), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C4D3H4N3O
Numero CAS:
Peso molecolare:
116.14
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

Forma fisica

liquid

Caratteristiche

Snap-N-Spike®/Snap-N-Shoot®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

100 μg/mL ((50:50) MeOH:Water)

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

O=C1CN(C([2H])([2H])[2H])C(N1)=N

InChI

1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/I1d3
DDRJAANPRJIHGJ-UEMYLDGTSA-N

Descrizione generale

Creatinine is excreted at fairly constant rates in the absence of renal disease and commonly used as benchmark in urinary biomarker analysis. Serum creatinine levels are useful indicators of renal function and have been implicated in diabetes, cardiovascular and circulatory diseases. This stable-labeled internal standard is suitable for quantification of creatinine levels by LC/MS or GC/MS for applications in clinical diagnostic, urine drug testing or forensic analysis.

Applicazioni


  • Quantification in biofluids: Creatinine-D₃ is crucial for the quantification of gut microbiota dysbiosis-related organic acids in human urine. This study demonstrates the utility of LC-MS/MS in assessing microbiome health and its impact on metabolic pathways, highlighting the compound′s role in biochemical research and clinical diagnostics (Lee et al., 2022).

  • Urine creatinine measurement: The development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for measuring creatinine in human urine showcase Creatinine-D₃ as a vital standard. This method is pivotal for ensuring accurate and reliable results in clinical and biochemical assays, particularly in kidney function testing (Fraselle et al., 2015).

  • Enhanced detection techniques: Creatinine-D₃ is used in innovative analytical techniques like reactive-thermal desorption-extractive electrospray-ion mobility-tandem mass spectrometry. This method allows for the direct determination of urinary creatinine, providing faster, more sensitive analyses suitable for rapid clinical assessments (Devenport et al., 2014).

  • Tracking creatine metabolism: In research exploring the metabolism of ingested creatine, Creatinine-D₃ is utilized to trace its metabolic fate in urine, plasma, and red blood cells. This application is crucial for studies on dietary supplements and their impact on health, particularly in sports science and nutrition (MacNeil et al., 2005).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Prodotti correlati

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1

Organi bersaglio

Eyes

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

75.2 °F

Punto d’infiammabilità (°C)

24 °C


Certificati d'analisi (COA)

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Creatine United States Pharmacopeia (USP) Reference Standard

USP

1150320

Creatine

Creatine anhydrous

Sigma-Aldrich

C0780

Creatine

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