900831

3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid

• Sinonimo/i: Carboxyl diazirine alkyne, Probe building block
• Formula empirica (notazione di Hill): C₈H₁₀N₂O₂
• Numero CAS: 1450754-37-6
• Peso molecolare: 166.18
• Numero MDL: MFCD31433997
• Codice UNSPSC: 12352106

Proprietà

• Forma fisica: liquid
• Livello qualitativo: 100
• Impiego in reazioni chimiche: reaction type: click chemistry
• Disponibilità: available only in USA
• Temperatura di conservazione: −20°C
• Stringa SMILE: C#CCCC1(N=N1)CCC(O)=O

Descrizione

Applicazioni

Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Altre note

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Technology Spotlight: Trifuctional Probe Building Blocks

Informazioni sulla sicurezza

• Pittogrammi: GHS02
• Avvertenze: Danger
• Indicazioni di pericolo: H242
• Consigli di prudenza: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classi di pericolo: Self-react. C
• Codice della classe di stoccaggio: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable