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152757

Sigma-Aldrich

1,4-Naphthoquinone

97%

Sinonimo/i:

α-Naphthoquinone

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About This Item

Formula empirica (notazione di Hill):
C10H6O2
Numero CAS:
130-15-4
Peso molecolare:
158.15
Beilstein:
878524
Numero CE:
204-977-6
Numero MDL:
MFCD00001676
Codice UNSPSC:
12352100
ID PubChem:
24849257
NACRES:
NA.22

Livello qualitativo

200

Saggio

97%

Stato

powder

Punto di fusione

119-122 °C (lit.)

Gruppo funzionale

ketone

Stringa SMILE

O=C1C=CC(=O)c2ccccc12

InChI

1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H
FRASJONUBLZVQX-UHFFFAOYSA-N

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Applicazioni

1,4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities. It was also used to inhibit the acetyltransferase activity.

Avvertenze

Danger

Indicazioni di pericolo

H301,H314,H317,H330,H335,H410

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

285.8 °F

Punto d’infiammabilità (°C)

141 °C

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCD6229
BCCB2228
BCBZ4058
BCBV3637
BCBS4148V

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p-Benzochinone reagent grade, ≥98%

Sigma-Aldrich

B10358

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1,4-Dihydroxy-2-naphthoic acid 97%

Sigma-Aldrich

281255

1,4-Dihydroxy-2-naphthoic acid

Anthraquinone 97%

Sigma-Aldrich

A90004

Anthraquinone

9,10-Phenanthrenequinone ≥99%

Sigma-Aldrich

156507

9,10-Phenanthrenequinone

Lapachol 98%

Sigma-Aldrich

142905

Lapachol

Eduardo Coelho-Cerqueira et al.
Chemical biology & drug design, 83(4), 401-410 (2013-10-30)
Monoamine oxidase (MAO) action has been involved in the regulation of neurotransmitters levels, cell signaling, cellular growth, and differentiation as well as in the balance of the intracellular polyamine levels. Although so far obscure, MAO inhibitors are believed to have
Rita Gatti et al.
Analytical and bioanalytical chemistry, 405(2-3), 817-825 (2012-07-24)
The use of 1,4-naphthoquinone as an advantageous pre-column reagent for liquid chromatography analysis of aliphatic thiol compounds is proposed. The compound reacts selectively in mild conditions (5 min at room temperature; pH 7.5) with thiol function. The resulting adducts were
Paula F Carneiro et al.
Bioorganic & medicinal chemistry, 20(16), 4995-5000 (2012-07-17)
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane
Yu Shang et al.
Environmental science & technology, 46(5), 2935-2942 (2012-02-01)
Airborne quinones contribute to adverse health effects of ambient particles probably because of their ability to generate hydroxyl radicals (·OH) via redox cycling, but the mechanisms remain unclear. We examined the chemical mechanisms through which 1,4-naphthoquinone (1,4-NQ) induced ·OH, and
Daniela M Santos et al.
Molecular neurobiology, 47(1), 313-324 (2012-10-12)
Naphthoquinones are bioactive compounds widespread in nature that impact on several cellular pathways, including cell proliferation and survival, by acting as prooxidants and electrophiles. We have previously described the role of the synthetic isoxazole condensed 1,4-naphthoquinone derivative 1a in preventing
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Protocolli

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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