142662

Chlorosulfonyl isocyanate

98%

• Sinonimo/i: CSI
• Formula condensata: ClSO₂NCO
• Numero CAS: 1189-71-5
• Peso molecolare: 141.53
• Beilstein: 1237247
• Numero CE: 214-715-2
• Numero MDL: MFCD00011608
• Codice UNSPSC: 12352100
• ID PubChem: 24848531
• NACRES: NA.22

Proprietà

• Tensione di vapore: 5.57 psi ( 20 °C)
• Livello qualitativo: 200
• Saggio: 98%
• Forma fisica: liquid
• Indice di rifrazione: n20/D 1.447 (lit.)
• P. eboll.: 107 °C (lit.)
• Punto di fusione: −44 °C (lit.)
• Densità: 1.626 g/mL at 25 °C (lit.)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: ClS(=O)(=O)N=C=O
• InChI: 1S/CClNO3S/c2-7(5,6)3-1-4; WRJWRGBVPUUDLA-UHFFFAOYSA-N
• Informazioni sul gene: human ... ABCB1(5243) , FPR1(2357)

Descrizione

Descrizione generale

Chlorosulfonyl isocyanate is classified as an isocyanate and is widely used as a reagent in sulfonylation and carbamoylation reactions.Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.

Applicazioni

• Chlorosulfonyl isocyanate was used in synthesis and biochemical characterization of new class of membrane-associated glycosyltransferase inhibitors.
• It is synthetically versatile reagent and was used in the preparation of amides, lactams and triazocinones.
• It was employed in regio- and diastereoselective introduction of a protected amino group in synthesis of chiral, polyhydroxylated piperidines.
• It was used as reagent during the synthesis of novel sulfamides.

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H314,H317,H334
• Consigli di prudenza: P261 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Rischi supp: EUH014
• Codice della classe di stoccaggio: 8A - Combustible corrosive hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): >230.0 °F
• Punto d’infiammabilità (°C): > 110 °C
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter