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1338007

USP

丙米嗪 盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐

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About This Item

经验公式（希尔记法）:
C19H24N2 · HCl
CAS号:
113-52-0
分子量:
316.87
MDL號碼:
MFCD00012669
分類程式碼代碼:
41116107
PubChem物質ID:
329750156
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

imipramine

製造商／商標名

USP

應用

pharmaceutical (small molecule)

格式

neat

SMILES 字串

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChI 密鑰

XZZXIYZZBJDEEP-UHFFFAOYSA-N

基因資訊

human ... SLC6A2(6530) , SLC6A4(6532)

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相关类别

一般說明

本产品按照现行药典要求提供和指定。所有为支持本产品而提供的信息，包括 SDS 和任何产品信息小册子，均由药典颁发机构制定和发布。如需进一步信息和支持，请访问现行药典网站。

應用

Imipramine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Imipramine Hydrochloride Tablets
  • Imipramine Hydrochloride Injection
  • Desipramine Hydrochloride
  • Clomipramine Hydrochloride
  • Desipramine Hydrochloride Tablets
  • Trimipramine Maleate

生化／生理作用

三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 Ki 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（Ki = 25 μM）。

分析報告

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药，不可用于诊断、治疗或治愈任何疾病。

其他說明

可能适用相应的销售限制。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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丙咪嗪标准液 CRM 盐酸盐 溶液 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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丙咪嗪标准液 CRM 盐酸盐 溶液

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胰岛素 人

Ritabrata Banerjee et al.
Psychiatry investigation, 11(3), 297-306 (2014-08-12)
The present study aimed to investigate whether graded doses of Bacopa Monniera (BM) extract could produce antidepressant-like effects in chronic unpredictable stress (CUS) induced depression in rats and its possible mechanism(s). Rats were subjected to an experimental setting of CUS.
Kazumi Miyawaki et al.
Journal of pharmacological sciences, 127(3), 382-390 (2015-04-04)
Biological rhythms are critical in the etiology of mood disorders; therefore, effective mood disorder treatments should address rhythm disturbances. Among the variables synchronized with the light-dark cycle, spontaneous activity in rodents is useful for investigating circadian rhythms. However, previous studies
Helena Domin et al.
Behavioural brain research, 273, 23-33 (2014-07-22)
The glutamatergic predominance in the excitatory-inhibitory balance is postulated to be involved in the pathogenesis of depression. Such imbalance may be induced by astrocyte ablation which reduces glutamate uptake and increases glutamate level in the synaptic cleft. In the present
Juliana O G Nascimento et al.
Brain research bulletin, 109, 39-45 (2014-10-08)
The dorsomedial hypothalamus (DMH) has long been associated with the regulation of escape, a panic-related defensive response. Previous evidence has shown that the activation of serotonin (5-HT) 1A and 2A receptors impairs escape behavior induced by the electrical stimulation of
Gu Ping et al.
Pharmacology, biochemistry, and behavior, 124, 5-12 (2014-05-23)
Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin, and is safe and well tolerated in hypertensive patients. Population-based studies have suggested a positive
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