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V8379

Sigma-Aldrich

Human Vitronectin

from human plasma, powder, suitable for cell culture

别名:

血清扩散因子

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About This Item

CAS号:
83380-82-9
MDL號碼:
MFCD00132575
分類程式碼代碼:
12352202
NACRES:
NA.75

product name

玻连蛋白 来源于人类血浆, lyophilized powder, BioReagent, suitable for cell culture

生物源

human plasma

品質等級

300

產品線

BioReagent

形狀

lyophilized powder

分子量

A subunit 75 kDa
B subunit 65 kDa

包裝

pkg of 50 μg

技術

cell culture | mammalian: suitable

表面覆盖率

0.1 μg/cm2

溶解度

water: soluble 0.050 mg/mL, clear, colorless

UniProt登錄號

P04004

運輸包裝

ambient

儲存溫度

2-8°C

基因資訊

human ... VTN(7448)

相关类别

應用

玻连蛋白可用于具有整联蛋白受体（与玻连蛋白结合）的细胞，包括血小板、内皮细胞、黑素瘤细胞和骨肉瘤。推荐将其作为细胞培养基质成分，浓度为 0.1 μg/cm2。附着的最佳条件取决于细胞系和具体应用。

生化／生理作用

玻连蛋白结合糖胺聚糖，作为补体系统的细胞溶解攻击复合物的一种抑制剂，在凝血过程中与凝血酶和抗凝血酶 III 相互作用，并可能在凝血途径中发挥作用。

成分

玻连蛋白是一种存在于血浆和组织中的糖蛋白，并且是血浆中与纤连蛋白结合的主要细胞粘附蛋白之一。玻连蛋白的 N-末端残基与生长调节素 B 相同，随后的序列是与特定细胞表面受体相互作用的 R-G-D 序列。玻连蛋白的中心结构域富含疏水残基。C 末端附近是富含精氨酸的区域，具有肝素结合活性。

注意

该冻干品应在 2-8℃ 下干燥储存。在这些条件下，它可以稳定至少 2 年。等分试样应储存在 -20°C 或 -70°C，但应避免反复冻融。

準備報告

该产品作为细胞培养物检测的冻干品（来自缓冲盐水）。由于玻连蛋白对亲水表面具有强亲和力，建议在操作过程中使用聚丙烯容器。每瓶产品可以重悬于 1mL 水中。然后应使用 0.2μm 膜对储备溶液进行过滤灭菌，等分并冷冻以便长期保存。

免責聲明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Theodora Chatzisideri et al.
Journal of medicinal chemistry, 65(1), 271-284 (2021-12-31)
c(RGDyK)-based conjugates of gemcitabine (GEM) with the carbonate and carbamate linkages in the 6-OH group of GEM were synthesized for the targeted delivery of GEM to integrin αvβ3, overexpressing cancer cells to increase the stability as well as the tumor
The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.
Margheri F, Luciani C, Taddei ML, et al.
Oncotarget, 5(6), 1538-1553 (2014)
Francesca Posa et al.
Biomaterials, 267, 120484-120484 (2020-11-04)
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying single BMP-2 dimers are prepared
Lorenzo Sernissi et al.
Bioorganic & medicinal chemistry, 24(4), 703-711 (2016-01-13)
4-Amino- and 5-amino-cyclopropane pipecolic acids (CPAs) with cis relative stereochemistry between the carboxylic and amino groups were used as templates to prepare cyclic peptidomimetics containing the RGD sequence as possible integrin binders. The peptidomimetic c(RGD8) built on the 5-amino-CPA displayed
Ta-Chun Kao et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 102(3), 463-476 (2013-09-17)
Cancer-initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)-grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix-coated dishes. CSCs persist in tumors as
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