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一般說明
2-硫脲嘧啶(2-Thiouracil)是尿嘧啶的硫代衍生物，是一种嘧啶核碱基。这种抗甲状腺药物在H2O &有机溶剂中的溶解度较低。
應用
2-硫脲嘧啶可用于：
- 银溶胶和膜基底的合成和表征，以及它们在表面增强拉曼光谱(SERS)中的应用。
- 研究其在二氧化钛(TiO2)纳米粒子改性金电极上的电氧化行为和测定方法
- 通过时间分辨光电子能谱研究甲基化对2-硫脲嘧啶的失活机制或三重态动力学的影响
生化／生理作用
2-硫尿嘧啶可作为抗癌、抗甲状腺和抗病毒剂。2-硫脲嘧啶是一种选择性黑色素瘤探测物和神经元一氧化氮合酶的竞争性抑制剂。可与金(Au)、铬(Cr)、锌(Zn)和银(Ag)等过渡金属形成络合物。2-硫脲嘧啶可加入组织培养基，在化疗期间抑制病毒复制或从感染组织转移到健康组织。
訊號詞
Warning
危險聲明
危險分類
Carc. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
A Palumbo et al.
FEBS letters, 485(2-3), 109-112 (2000-11-30)
2-thiouracil (TU), an established antithyroid drug and melanoma-seeker, was found to selectively inhibit neuronal nitric oxide synthase (nNOS) in a competitive manner (K(i)=20 microM), being inactive on the other NOS isoforms. The drug apparently interfered with the substrate- and tetrahydrobiopterin
Silver colloid and film substrates in surface-enhanced Raman scattering for 2-thiouracil detection
Al-Shalalfeh MM, et al.
Royal Society of Chemistry Advances, 6, 75282-75292 (2016)
Karina Kraszewska et al.
Bioorganic & medicinal chemistry, 19(7), 2443-2449 (2011-03-15)
4-Pyrimidinone ribofuranoside (H(2)o(4)U) and 4-pyrimidinone 2'-deoxyribofuranoside (dH(2)o(4)U) were synthesized by the oxidative desulfurization of parent 2-thiouracil nucleosides with m-chloroperbenzoic acid. The crystal structures of H(2)o(4)U and dH(2)o(4)U and their conformations in solution were determined and compared with corresponding 2-thiouracil and
Hiroyuki Minami et al.
The Journal of prosthetic dentistry, 106(6), 378-385 (2011-12-03)
Although the effectiveness of primers for resin bonding to noble alloys has been demonstrated, no effective clinical technique for bonding to noble metal ceramic alloys has been established. The purpose of this study was to evaluate the effects of metal
K P Prasanthkumar et al.
The journal of physical chemistry. A, 116(44), 10712-10720 (2012-10-16)
The reaction of hydroxyl radical ((•)OH) with the nucleic acid base analogue 2-thiouracil (1) has been studied by pulse radiolysis experiments and DFT. The generic intermediate radicals feasible for the (•)OH reactions with 1, namely, one electron oxidation product (1(•+))
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