SML3529
GB83
≥98% (HPLC)
别名:
GB 83, GB-83, N-[(1S)-1-(Cyclohexylmethyl)-2-[[(1S,2S)-1-[(2,3-dihydrospiro[1H-indene-1,4′-piperidin]-1′-yl)carbonyl]-2-methylbutyl]amino]-2-oxoethyl]-5-isoxazolecarboxamide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C32H44N4O4
CAS号:
分子量:
548.72
MDL號碼:
分類程式碼代碼:
51111800
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
CC[C@@H]([C@H](NC([C@@H](NC(C1=CC=NO1)=O)CC2CCCCC2)=O)C(N3CCC4(CC3)CCC5=C4C=CC=C5)=O)C
InChI
1S/C32H44N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-12,14,18,22-23,26,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22?,26-,28-/m0/s1
InChI 密鑰
ZXMXAOYWSLZLQM-NZNGGYBSSA-N
生化／生理作用
GB83 is a serum stable, potent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 µM) that reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice
Muley MM, Krustev E, Reid AR, McDougall JJ
Journal of Neuroinflammation, 14, 168-168 (2017)
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