所有图片(1)
About This Item
经验公式（希尔记法）:
C8H7NO2S
CAS号:
分子量:
181.21
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥97% (HPLC)
形狀
solid
儲存條件
desiccated
溶解度
DMSO: soluble >10 mg/mL, clear
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
NS(=O)(=O)C#Cc1ccccc1
InChI
1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI 密鑰
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
應用
菲丝菌素-μ 已用于:
- 处理小胶质细胞系以分析其对M1样和M2样表型的神经保护作用
- 作为热休克蛋白（HSP）-70抑制剂用于处理转染的Marc-145细胞
- 抑制热休克相关蛋白70（heat shock cognate，Hsc70）以阐明小鼠胚胎干细胞的热休克伴侣蛋白
生化／生理作用
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。PFT μ可从致死γ -辐射诱导的细胞死亡中解救细胞。由于pifithrin- μ仅关闭p53-线粒体途径而不影响p53的转录功能，所以它比pifithrin-α 具有更优的性能。
在缺氧缺血（HI）诱发的新生儿脑病的临床前模型中，菲丝菌素μ（PFT-μ）具有防止细胞死亡的神经保护能力。它通过抑制分子伴侣热休克蛋白（HSP）-70与其底物的相互作用来抑制核因子ΙB（NF-ΙB）通路。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Julia I-Ju Leu et al.
ACS chemical biology, 9(11), 2508-2516 (2014-08-26)
The stress-inducible mammalian heat shock protein 70 (HSP70) and its bacterial orthologue DnaK are highly conserved nucleotide binding molecular chaperones. They represent critical regulators of cellular proteostasis, especially during conditions of enhanced stress. Cancer cells rely on HSP70 for survival
J I-Ju Leu et al.
Molecular cell, 36(1), 15-27 (2009-10-13)
The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70 expression is elevated in many cancers, contributing to tumor cell survival and resistance to therapy. We have determined that a small molecule
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication
Dong S, et al.
Journal of Proteomics, 146, 58-69 (2016)
Wonkyoung Cho et al.
Molecular and cellular biology, 39(9) (2019-02-13)
Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of diagnostic and preventive strategies. Heat shock protein 70 (HSP70) acts
Fernando Mérida et al.
International journal of nanomedicine, 15, 419-432 (2020-02-06)
Magnetic Fluid Hyperthermia (MFH) is a promising adjuvant for chemotherapy, potentiating the action of anticancer agents. However, drug delivery to cancer cells must be optimized to improve the overall therapeutic effect of drug/MFH combination treatments. The aim of this work
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