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Merck

SML1221

Sigma-Aldrich

度他雄胺

≥98% (HPLC)

别名:

17β-N-[2,5-双(三氟甲基)苯基]-氨基甲酰基-4-氮杂-5α-雄烷-1-烯-3-酮, (5α,17β)-N-[2,5-双(三氟甲基)苯基] -3-氧代-4-氮杂杂芳-1-烯-17-羧酰胺

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About This Item

经验公式(希尔记法):
C27H30F6N2O2
分子量:
528.53
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +18 to +24°, c = 1 in chloroform-d

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1

InChI

1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChI 密鑰

JWJOTENAMICLJG-QWBYCMEYSA-N

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生化/生理作用

度他雄胺是1型和2型5α-还原酶同工酶的有效双重抑制剂 (IC50 = 6 nM 5-AR1; 7 nM 5-AR2)。度他雄胺可阻断睾丸激素向二氢睾丸酮的转化,并在临床上用于治疗良性前列腺增生 (BPH)。

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Carc. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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