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Merck
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文件

F9397

Sigma-Aldrich

氟他胺

别名:

2-甲基-N-[4-硝基-3-（三氟甲基）苯基]丙酰胺

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About This Item

经验公式（希尔记法）:
C11H11F3N2O3
CAS号:
13311-84-7
分子量:
276.21
EC號碼:
236-341-9
MDL號碼:
MFCD00072009
分類程式碼代碼:
51111800
PubChem物質ID:
24278446
NACRES:
NA.77

起源

Schering Plough

SMILES 字串

CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI

1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

InChI 密鑰

MKXKFYHWDHIYRV-UHFFFAOYSA-N

基因資訊

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

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應用

氟他胺已被用于考察睾丸素对胶质细胞源性神经营养因子（Gdnf）mRNA的体外生产的影响。它还被用于研究氟他胺对肛门生殖器距离和乳头保留的影响。

生化／生理作用

氟他胺是一种非甾体抗雄激素药。它包括硝基芳香结构。氟他胺是睾丸素和二氢睾丸素受体的强效竞争剂。它是一种强效的肝毒素。

特點和優勢

该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2

標靶器官

Liver

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Shuchen Gu et al.
Cellular signalling, 25(1), 66-73 (2013-01-15)
Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in colon tumor cells. This mAR-induced actin reorganization was recognized as a critical initial event, controlling apoptosis and inhibiting cell migration. The
N A Spry et al.
Prostate cancer and prostatic diseases, 16(1), 67-72 (2012-08-22)
To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST). Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat
Hass U, et al.
Environmental Health Perspectives, 115(Suppl 1), 122-128 (2007)
Flutamide-induced hepatotoxicity: ethical and scientific issues
Giorgetti R, et al.
European Review for Medical and Pharmacological Sciences, 21(1 Suppl), 69-77 (2017)
Palakkil Mavilavalappil Sandeep et al.
Metabolic syndrome and related disorders, 13(6), 248-254 (2015-04-29)
Polycystic ovary syndrome (PCOS) is a major hyperandrogenic disorder. Many drugs prescribed specifically to treat PCOS have side effects; however, previous studies suggest that natural therapeutics including botanicals may be less invasive and equally effective for the management of PCOS.
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