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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
protect from light
溶解度
DMSO: >5 mg/mL
H2O: insoluble
起源
AstraZeneca
SMILES 字串
CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
InChI
1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI 密鑰
LKJPYSCBVHEWIU-UHFFFAOYSA-N
基因資訊
human ... AR(367)
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應用
比卡鲁胺已用作前列腺、膀胱癌细胞系和人胚胎骨骼肌细胞中的雄激素受体（AR）拮抗剂。它还被用作RPMI 1640 的补充剂，用于培养雄激素非依赖性LNCaP（LNCaP-AI）细胞系。
生化／生理作用
比卡鲁胺 (CDX) 是一种非杀菌的雄激素受体 (AR) 拮抗剂，是纯抗雄激素。它通过平衡组蛋白乙酰化/去乙酰化和共调剂募集发挥作用。比卡鲁胺(CDX)消除了雄激素介导的表达。例如，前列腺癌、PLZF（早幼粒细胞白血病锌指蛋白）和GADD45γ中的MMP13上调（生长停滞和可诱导的DNA损伤，γ）。通过雄激素，对PI3K /AKT磷酸化进行非基因组、非转录依赖性刺激，抑制比卡鲁胺(CDX)。
特點和優勢
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訊號詞
Danger
危險聲明
危險分類
Aquatic Chronic 1 - Carc. 2 - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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