SML0494

VU0361737

≥98% (HPLC)

• 别名: CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• 经验公式（希尔记法）: C₁₃H₁₁ClN₂O₂
• CAS号: 1161205-04-4
• 分子量: 262.69
• MDL號碼: MFCD16618402
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825444
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: film
• 顏色: white
• 溶解度: DMSO: 15 mg/mL (clear solution)
• 儲存溫度: 2-8°C
• SMILES 字串: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• InChI: 1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
• InChI 密鑰: ARYUXFNGXHNNDM-UHFFFAOYSA-N

说明

生化／生理作用

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC₅₀ values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

特點和優勢

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319
• 防範說明: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable