所有图片(1)
About This Item
经验公式（希尔记法）:
C15H11F2N3
CAS号:
分子量:
271.26
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 15 mg/mL (clear solution)
儲存溫度
2-8°C
SMILES 字串
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI 密鑰
AWIVHRPYFSSVOG-UHFFFAOYSA-N
應用
Spautin-1 已作为自噬抑制剂用于：
- 研究其对氧诱导视网膜病变小鼠模型中血管、神经胶质和神经元改变的影响
- 评估预处理对犬骨肉瘤细胞阿霉素反应的效果
- 在 Luminex 试验中研究其对氧化应激树突状细胞 (OS-DC) 产生白细胞介素 (IL)-6 的影响
生化／生理作用
Spautin-1 抑制两种泛素特异性肽酶 USP10 和 USP13 的活性，引起 III 类 PI3 激酶复合物的蛋白酶体降解增加，已被证明可调节自噬。
特异性强的自噬抑制剂-1（Spautin-1）是一种小分子，可以抑制自噬并诱导癌细胞死亡。它可通过降解 beclin-1 来抑制自噬。Spautin-1 可提高放射治疗和化学疗法在各种人类癌细胞系中的效率。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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