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品質等級
化驗
≥95% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
2-8°C
InChI
1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChI 密鑰
MSSXBKQZZINCRI-UHFFFAOYSA-N
應用
MHY1485已被用于：
- 研究哺乳动物雷帕霉素靶蛋白mTOR信号传导对 体外 O-GlcNAcylation糖基化修饰的作用
- 抑制自我吞噬
- 作为mTOR 激动剂证明 O-连接N-乙酰葡糖胺转移酶- RNA解旋酶 p68 (OGT-DDX5) 调节结肠直肠癌细胞的增殖和转移。
生化／生理作用
MHY1485是mTOR激活剂，可通过抑制自噬体和溶酶体之间的融合，有效抑制自噬。
MHY1485结合雷帕霉素（mTOR）的哺乳动物靶标，并刺激其作用。MHY1485可以穿透细胞。它防止紫外诱导的角化细胞和成纤维细胞的氧化应激。
特點和優勢
这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling
Yang Bo, et al.
Oncotarget, 8(8), 12775-12775 (2017)
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5
Wu N, et al.
Journal of Cellular and Molecular Medicine, 23(2), 1354-1362 (2019)
ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic
Gan W, et al.
BMC Cell Biology, 18(1), 22-22 (2017)
Duc-Vinh Pham et al.
Journal of experimental & clinical cancer research : CR, 41(1), 9-9 (2022-01-07)
Adiponectin, the most abundant adipokine derived from adipose tissue, exhibits a potent suppressive effect on the growth of breast cancer cells; however, the underlying molecular mechanisms for this effect are not completely understood. Fatty acid metabolic reprogramming has recently been
MHY1485 activates mTOR and protects osteoblasts from dexamethasone
Zhao S, et al.
Biochemical and biophysical research communications, 481(3-4), 212-218 (2016)
实验方案
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