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Merck
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文件

B1793

Sigma-Aldrich

Bafilomycin A1

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor

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About This Item

经验公式（希尔记法）:
C35H58O9
CAS号:
88899-55-2
分子量:
622.83
Beilstein:
4730700
MDL號碼:
MFCD06795130
分類程式碼代碼:
12352200
PubChem物質ID:
24891613
NACRES:
NA.77

product name

巴弗洛霉素A1 来源于灰色链霉菌, ≥90% (HPLC)

品質等級

300

化驗

≥90% (HPLC)

形狀

film

抗生素活性譜

fungi

作用方式

DNA synthesis | interferes
enzyme | inhibits

儲存溫度

−20°C

SMILES 字串

CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI 密鑰

XDHNQDDQEHDUTM-JQWOJBOSSA-N

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一般說明

化学结构：大环内酯

應用

Bafilomycin A1已用于：
  • 作为自噬抑制剂，研究其对人肝细胞脂肪变性的影响
  • 作为液泡型H+ -ATPase抑制剂，研究其对小鼠INS-1细胞活力、PI阳性细胞百分比和葡萄糖刺激胰岛素分泌(GSIS)的影响
  • 作为液泡型H+ -ATPase抑制剂，研究其对人SH-SY5Y细胞tau蛋白降解的影响

生化／生理作用

Bafilomycin A1抑制自噬体-溶酶体融合和自噬体酸化，这是自噬过程中需要维持自噬通量和细胞稳态的步骤。
动物细胞、植物细胞和微生物中液泡型 H+-ATPase（V-ATPase）的特异性抑制剂。

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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Jens Niewoehner et al.
Neuron, 81(1), 49-60 (2014-01-15)
Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB). We report that by manipulating the binding mode of an antibody fragment to the transferrin receptor (TfR)
T Umata et al.
The Journal of biological chemistry, 265(35), 21940-21945 (1990-12-15)
The role of vacuolar-type H(+)-ATPase (V-ATPase) in the cytotoxic action of diphtheria toxin (DT) was studied by using bafilomycin A1, a specific inhibitor of V-ATPase. Studies with acridine orange showed that the acidification of intracellular acidic compartments was inhibited strongly
Ru Li et al.
Phytopathology, 109(8), 1417-1424 (2019-03-13)
The vacuolar H+-ATPases (V-ATPases) are conserved ATP-dependent proton pumps that acidify intracellular compartments in eukaryotic cells. The role of Cpvma1, a V-ATPase catalytic subunit A of Cryphonectria parasitica, was investigated by generating cpvma1-overexpressing and cpvma1-silenced strains. The mutant strains were
Feng-Xia Guo et al.
Cell death and differentiation, 26(9), 1670-1687 (2019-01-27)
Atherosclerosis is a progressive, chronic inflammation in arterial walls. Long noncoding RNAs (lncRNAs) participate in inflammation, but the exact mechanism in atherosclerosis is unclear. Our microarray analyses revealed that the levels of lncRNA-FA2H-2 were significantly decreased by oxidized low-density lipoprotein
Kun Wang et al.
International journal of molecular sciences, 20(14) (2019-07-25)
The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apoptosis, thus enhancing the efficacy of chemotherapeutic
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