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Merck
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Key Documents

SML0189

Sigma-Aldrich

Indinavir sulfate salt hydrate

≥98% (HPLC), powder, antiretroviral agent

别名:

2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate hydrate, Crixivan hydrate, L-735,524 hydrate, MK-639 hydrate

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About This Item

经验公式（希尔记法）:
C36H47N5O4·H2SO4 · xH2O
分子量:
711.87 (anhydrous basis)
分類程式碼代碼:
51111800
NACRES:
NA.77

product name

Indinavir sulfate salt hydrate, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

H2O: ≥15 mg/mL

起源

Merck & Co., Inc., Kenilworth, NJ, U.S.

儲存溫度

2-8°C

應用

Indinavir sulfate salt hydrate may be used in HIV-related cell signaling studies.

生化／生理作用

Indinavir sulfate is an antiviral HIV protease inhibitor.
Indinavir sulfate suppresses the replication of HIV and is an important component of antiretroviral therapy for initial treatment of HIV infection. It is known to cause renal and urologic toxicity.

特點和優勢

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Ryan D Cooper et al.
Nephron. Clinical practice, 118(3), c262-c268 (2011-01-08)
The introduction of potent combination antiretroviral therapy (ART) in the treatment of HIV infection has permitted reliable control of disease progression and has markedly improved survival among people with HIV. As a result, health care providers and patients have shifted
Benjamin Seyer et al.
Journal of neurochemistry, 153(4), 485-494 (2019-09-27)
Ethyl2-acetylamino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate (HFI-419), the benzopyran-based inhibitor of insulin-regulated aminopeptidase (IRAP), has previously been shown to improve spatial working and recognition memory in rodents. However, the mechanism of its cognitive-enhancing effect remains unknown. There is a close correlation between dendritic spine density

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