推荐产品
生物源
plant
化驗
≥95% (TLC)
形狀
powder
顏色
yellow to orange
mp
213.0-214.0 °C
溶解度
DMSO: 2 mg/mL
儲存溫度
−20°C
SMILES 字串
Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC
InChI
1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H
InChI 密鑰
SUPBMPBJXZDANZ-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
一般說明
Chelerythrine chloride (CHE), a benzophenanthridine alkaloid is an inhibitor of protein kinase C (PKC). It is the active component of Macleaya cordata.
應用
Chelerythrine chloride has been used:
- as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity
- for in vitro Xenopus experiments
- as a PKC inhibitor in HL-1 cells, to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression
生化／生理作用
Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells. It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina.
特點和優勢
This compound is featured on the P2 Receptors: P2X Ion Channel Family and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression
Song X, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1853(2), 513-521 (2015)
Shi-Yang Li et al.
Scientific reports, 7(1), 15317-15317 (2017-11-12)
The present study was performed to explore the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central nucleus of amygdala (CeA) in normal rats and rats with neuropathy, and the involvement of GalR 1
W D Jarvis et al.
Cancer research, 54(7), 1707-1714 (1994-04-01)
The present studies were undertaken to characterize further the potential role of protein kinase C (PKC) in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. The capacity of acute exposure to specific and nonspecific pharmacological inhibitors of PKC to
Doxazosin stimulates galectin-3 expression and collagen synthesis in HL-1 cardiomyocytes independent of protein kinase C pathway
Qian X, et al.
Frontiers in Pharmacology, 7, 495-495 (2016)
Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium
Ahn BK, et al.
The Journal of Investigative Dermatology, 126(6), 1348-1355 (2006)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门