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Merck

SML0621

Sigma-Aldrich

WZB-117

≥98% (HPLC)

别名:

3-氟-1,2-亚苯基双(3-羟基苯甲酸酯), 3-羟基苯甲酸 1,1′-(3-氟-1,2-亚苯基)酯

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About This Item

经验公式(希尔记法):
C20H13FO6
分子量:
368.31
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(C1=CC=CC(O)=C1)OC2=C(F)C=CC=C2OC(C3=CC(O)=CC=C3)=O

InChI

1S/C20H13FO6/c21-16-8-3-9-17(26-19(24)12-4-1-6-14(22)10-12)18(16)27-20(25)13-5-2-7-15(23)11-13/h1-11,22-23H

InChI 密鑰

FRSWCCBXIHFKKY-UHFFFAOYSA-N

應用

WZB-117 已被用于研究其在肿瘤干细胞中的肿瘤起始能力。也用于研究葡萄糖拮抗剂对 2-NBDG(2-(N-(7-硝基苯并-2-氧杂-1,3-二唑-4-基)氨基)-2-脱氧葡萄糖)摄取的影响。

生化/生理作用

WBZ 117 是 H1299 肺癌和其他癌细胞中基础葡萄糖转运的抑制剂。
WZB-117 是一种不可逆抑制剂。在癌细胞中,WZB-117 通过在任何葡萄糖浓度下刺激细胞凋亡来防止细胞生长。它靶向肿瘤干细胞的自我更新和肿瘤起始能力。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.
Mira A, et al.
Oncotarget, 8(24), 38193-38193 (2017)
Meng Wei et al.
Biochemical and biophysical research communications, 503(2), 1154-1159 (2018-06-29)
Like tumour cells, during intraerythrocytic stage, Plasmodium-infected erythrocytes rely completely on glucose absorption from the blood circulation for energy metabolism. Glucose is taken up by glucose transporter 1 (GLUT1) on human red blood cells (RBCs) and glucose transporter 4 (GLUT4)
Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs.
Cheng X T, et al.
Neural Plast., 2018, 7-7 (2018)
Katharina Timper et al.
Cell metabolism, 31(6), 1189-1205 (2020-05-21)
Astrocytes represent central regulators of brain glucose metabolism and neuronal function. They have recently been shown to adapt their function in response to alterations in nutritional state through responding to the energy state-sensing hormones leptin and insulin. Here, we demonstrate
Keita Shibuya et al.
Oncotarget, 6(2), 651-661 (2014-12-22)
Increased glucose metabolism is now recognized as an emerging hallmark of cancer. Recent studies have shown that glucose metabolism is even more active in cancer stem cells (CSCs), a rare population of cancer cells with the capacity to self-renew and

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