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About This Item
经验公式（希尔记法）:
C14H20N2O3
CAS号:
分子量:
264.32
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
产品名称
SAHA, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: ≥15 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
ONC(=O)CCCCCCC(=O)Nc1ccccc1
InChI
1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChI 密鑰
WAEXFXRVDQXREF-UHFFFAOYSA-N
基因資訊
human ... HDAC1(3065) , HDAC2(3066) , HDAC3(8841) , HDAC6(10013)
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應用
SAHA可用于研究基因调控、转录调控和细胞信号转导。
生化／生理作用
SAHA或Vorinostat可促进导致细胞凋亡、分化和生长停滞的基因的转录。其已在淋巴瘤中获得有益结果，但在实体瘤中没有。
伏立诺他或辛二酰苯胺异羟肟酸（SAHA）是一种有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。其可抑制I类和II类HDAC，从而改变基因转录并诱导多种转化细胞中的细胞周期停滞和/或凋亡。
有效的、可逆的泛组蛋白去乙酰化酶（HDAC）抑制剂。
特點和優勢
该化合物是基因调控研究的推荐产品。点击此处，了解更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
訊號詞
Danger
危險聲明
危險分類
Muta. 2 - Repr. 1A
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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