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T8552

Sigma-Aldrich

曲古抑菌素A

≥98% (HPLC), from Streptomyces sp.

别名:

TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺

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About This Item

经验公式（希尔记法）:
C17H22N2O3
CAS号:
58880-19-6
分子量:
302.37
MDL號碼:
MFCD03848392
分類程式碼代碼:
12352200
PubChem物質ID:
24900542
NACRES:
NA.77

生物源

Streptomyces sp.

品質等級

300

化驗

≥98% (HPLC)

形狀

powder

溶解度

methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan
DMF: soluble
DMSO: soluble
H2O: insoluble
acetone: slightly soluble
acetonitrile: soluble
benzene: slightly soluble
chloroform: slightly soluble
ethanol: soluble
ethyl acetate: slightly soluble
lower alcohols: soluble

儲存溫度

−20°C

SMILES 字串

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChI 密鑰

RTKIYFITIVXBLE-QEQCGCAPSA-N

基因資訊

human ... HDAC1(3065) , HDAC4(9759) , HDAC6(10013) , HDAC8(55869)
mouse ... ENSMUSG00000061062(15181)
rat ... Hdac7a(84582)

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一般說明

Trichostatin A (TSA) is a potent and specific inhibitor of histone deacetylase (HDAC) activity. It is an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture.

應用

曲古抑菌素A(TSA)已用于克隆小鼠胚胎生产。TSA还用作LNCaP人前列腺癌细胞以及MON和HeLa细胞的组蛋白去乙酰化酶(HDAC)抑制剂。

生化／生理作用

抑制纳摩浓度的组蛋白脱乙酰基酶；组蛋白高乙酰化生成物会导致染色质弛豫并调节基因表达。可能参与多种细胞类型细胞周期过程，诱导G和G/M期细胞生长停滞；可能诱导细胞凋亡。增强靶向DNA的抗癌症剂的效力。

特點和優勢

该化合物是细胞凋亡和基因调控研究的特色产品。发现更多细胞凋亡和基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

準備報告

曲古抑菌素A可溶于甲醇，浓度为1.90 - 2.10 mg/ml，并生成一种透明无色至淡黄色/棕黄色的溶液。也可溶于二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、乙腈、乙醇和低级醇。曲古抑菌素A略溶于氯仿、乙酸乙酯、丙酮和苯。但不溶于水。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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