SMB00915

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)

≥95% (HPLC)

• 别名: BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
• 经验公式（希尔记法）: C₂₅H₄₀O₅
• CAS号: 27240-87-5
• 分子量: 420.58
• 分類程式碼代碼: 41141802
• NACRES: NA.25

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 顏色: white to beige
• mp: 153.5—154.5 °C
• 溶解度: chloroform: 20 mg/mL, colorless to light yellow
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(OC)CCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)C(O)C12C

说明

一般說明

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.

Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

應用

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.

特點和優勢

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

其他說明

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安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable