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Merck
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Key Documents

SCP0157

Sigma-Aldrich

甘氨酸-精氨酸-甘氨酸-天冬氨酸-丝氨酸-脯氨酸

别名:

GRGDSP Peptide, RGD Peptide

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About This Item

经验公式（希尔记法）:
C22H37N9O10
分子量:
587.58
分類程式碼代碼:
12352209
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥60%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro

一般說明

Gly-Arg-Gly-Asp-Ser-Pro（GRGDSP）是一种源自纤连蛋白的生物活性分子/肽。

應用

Gly-Arg-Gly-Asp-Ser-Pro （GRGDSP）已用于：
  • 涂布多孔板以通过结晶紫染色监测细胞附着
  • 处理幼仓鼠肾（BHK-21）细胞以研究 Arg-Gly-Asp （RGD）基序在日本脑炎病毒 (JEV) 复制中的作用
  • 阻断 INA-6 细胞中 RGD 依赖性整合素或整合素信号传导
  • 研究 RGD 结合整合素在 Gal-3 介导的细胞粘着中的作用

生化／生理作用

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP)是一种可溶性整合素阻断RGD肽。GRGDSP与其它RGD多肽一起广泛应用于整合素的研究。
Gly-Arg-Gly-Asp-Ser-Pro（GRGDSP）通过修饰心血管植入物的表面来刺激内皮化。GRGDSP 的主要细胞结合结构域有助于促进多种底物上的细胞粘着。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Shyam Patel et al.
Journal of biomedical materials research. Part A, 83(2), 423-433 (2007-04-25)
Vascular endothelium plays an important role in preventing thrombogenesis. Bioactive molecules such as fibronectin-derived peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Here we conjugated GRGDSP peptide to
Ines Lauria et al.
Acta biomaterialia, 62, 317-327 (2017-09-03)
Bionanoparticles based on filamentous phages or flexuous viruses are interesting candidates for meeting the challenges of tailoring biomineralization in hydrogel-based bone tissue substitutes. We hypothesized that hydroxyapatite crystal nucleation and matrix mineralization can be significantly increased by mineralization-inducing (MIP) and
Julia Dotterweich et al.
Cell communication and signaling : CCS, 12, 36-36 (2014-06-27)
CCN family member 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), belongs to the extracellular matrix-associated CCN protein family. The diverse functions of these proteins include regulation of cell migration, adhesion, proliferation, differentiation and survival/apoptosis, induction of angiogenesis
Antonín Sedlář et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Galectin-3 (Gal-3) is a β-galactoside-binding protein that influences various cell functions, including cell adhesion. We focused on the role of Gal-3 as an extracellular ligand mediating cell-matrix adhesion. We used human adipose tissue-derived stem cells and human umbilical vein endothelial

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