SAB4300135

Anti-phospho-PAK1/PAK2/PAK3 (pThr⁴²³/pThr⁴⁰²/pThr⁴²¹) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-ADE2 antibody produced in rabbit, Anti-CDKN1A antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit
• MDL號碼: MFCD02097133
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: 61-67 kDa; 68-74 kDa
• 物種活性: mouse, human, rat
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• 同型: IgG
• 免疫原序列: (R-S-TP-M-V)
• NCBI登錄號: NP_001121638.1; NP_001122092.1; NP_002568.2
• UniProt登錄號: Q13177
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pThr423/pThr402/pThr421)
• 基因資訊: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

说明

免疫原

Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.

特點和優勢

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標靶描述

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable