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Merck

P6188

Sigma-Aldrich

前列腺素 I2 钠盐

≥96% (HPLC), synthetic, powder

别名:

PGI2-钠, 依前列醇 钠盐, 前列环素 钠盐, (5Z,9 & # 945;,11 & # 945;,13E,15S)-6,9-环氧-11,15-二羟基前列腺素-5,13-迪恩-1-oic酸 钠盐

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About This Item

经验公式(希尔记法):
C20H31NaO5
CAS号:
分子量:
374.45
Beilstein:
6472195
EC號碼:
分類程式碼代碼:
12352401
eCl@ss:
42020658
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic

品質等級

化驗

≥96% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F in aqueous solution.)
ethanol: 50 mg/mL

官能基

carboxylic acid
hydroxyl

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]

InChI

1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1

InChI 密鑰

OURCVRVJQMLUNA-QFDVFERUSA-M

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應用

前列腺素I2钠盐已用于以下情形:
  • 制备储备溶液,用于血小板洗涤程序
  • 在富血小板血浆中用作补充剂,用于血小板制剂
  • 防止血小板激活

生化/生理作用

前列环素是血管内皮细胞中环氧合酶途径的一种短期产物。通过拮抗血栓烷A2和刺激血小板腺苷酸环化酶,用作血小板聚集的有效抑制剂。一氧化氮也在血管内皮中产生,抑制血小板聚集,调节诱导型环氧合酶的产生,并可与前列环素协同作用以减弱血栓形成过程。前列环素具有血管保护作用,保护动脉壁免受损伤引起的损伤,并保护肝脏和胃肠道的细胞。
前列环素治疗改善肺动脉高压的血流动力学。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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