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P5899

Sigma-Aldrich

Poly-ʟ-Lysine Hydrobromide

synthetic, mol wt ≥300,000, powder, γ-irradiated, suitable for cell culture, BioXtra

别名:

PDL HBr

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About This Item

CAS号:
25988-63-0
MDL號碼:
MFCD00237230
分類程式碼代碼:
12352202
eCl@ss:
32160406
PubChem物質ID:
24898718
NACRES:
NA.75

product name

聚-L-赖氨酸 氢溴酸盐, mol wt ≥300,000, lyophilized powder, γ-irradiated, BioXtra, suitable for cell culture

生物源

synthetic (organic)

品質等級

200

無菌

γ-irradiated

產品線

BioXtra

形狀

lyophilized powder

分子量

≥300,000

包裝

pkg of 5 mg

技術

cell culture | mammalian: suitable

表面覆盖率

4 μg/cm2

雜質

<10% water (by Karl Fischer)

溶解度

H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

Cl.NCCCCC(N)C(O)=O

InChI

1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1

InChI 密鑰

WBSCNDJQPKSPII-KKUMJFAQSA-N

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相关类别

應用

多聚-L-赖氨酸氢溴酸盐已用于包被:
  • 在一项虹鳟鱼肌小管形成的研究中在接种肌肉细胞前包被2孔培养板
  • 用于体外神经元干细胞分化的96孔板
  • 用于原代星形胶质细胞培养物的T75 瓶

生化／生理作用

多聚-L-赖氨酸可用作涂层物质，以确保细胞在培养物表面更好地附着。研究表明多聚-L-赖氨酸(PLL)包被的培养板中细胞生长速度加快。在包被PLL的底物上培养间充质干细胞可维持这些细胞的干性特征（stemness properties）并抑制衰老。包被PLL的培养板表现出改善的MSC生长，并使与细胞粘附、分化、增殖和信号传导相关的基因表达上调。此外，包被PLL的多孔表面改善细胞增殖和MSC的成骨分化。

成分

聚-L-赖氨酸是一种带正电荷的氨基酸聚合物，每个赖氨酸残基约有一个HBr。 氢溴酸盐可使聚-L-赖氨酸呈可溶于水的结晶形式。 在β结构中可能会发现少量的产物，因为HBr干扰氨基与羧基或含N或O部分之间的氢键。

注意

无菌溶液可在2-8℃条件下稳定保存2年。脱水保存在-20°C条件下。

分析報告

分子量基于粘度。同样通过 MALLS 分析。

其他說明

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Sonja Stadler et al.
BMC cell biology, 5(1), 44-44 (2004-11-24)
Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory. The internal organization of these chromosome territories is still largely unknown. We compared the large-scale chromatin structure of
Malgorzata J Podolska et al.
Journal of leukocyte biology, 106(6), 1359-1366 (2019-09-04)
The release of neutrophil extracellular traps (NETs) is one of the weapons neutrophils have in their armory. NETs consist of extracellular chromatin fibers decorated with a plethora of cytoplasmic and granular proteins, such as the antimicrobial serine protease neutrophil elastase
Gustavo Castro et al.
ISRN ophthalmology, 2013, 752161-752161 (2014-02-22)
Purpose. The purpose of this work was to evaluate the retinal integration and differentiation of neurospheres formed by stem cells and mouse neural progenitor cells injected intravitreally in mice eyes with retinal injury. Methods. Eight male C57BL mice, 8 weeks
Skye E Smith et al.
eNeuro, 7(4) (2020-08-02)
Aberrant migration of inhibitory interneurons can alter the formation of cortical circuitry and lead to severe neurologic disorders including epilepsy, autism, and schizophrenia. However, mechanisms involved in directing the migration of interneurons remain incompletely understood. Using a mouse model, we
Stuart B Mazzone et al.
Molecular neurobiology, 57(2), 949-963 (2019-10-21)
Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively
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